{"id":25884,"date":"2022-10-24T03:52:13","date_gmt":"2022-10-24T08:52:13","guid":{"rendered":"https:\/\/en.ennov.com\/?p=25884"},"modified":"2022-10-24T03:52:13","modified_gmt":"2022-10-24T08:52:13","slug":"causal-relationship","status":"publish","type":"post","link":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/","title":{"rendered":"Causal Relationship"},"content":{"rendered":"\n<p>The causal relationship between an\u00a0<a href=\"https:\/\/en.ennov.com\/glossary\/adverse-event\/\">AE\u00a0<\/a>and a suspected drug can be, according to the\u00a0WHO:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain\u2013 sufficient information provided to determine that no other reasonable explanation exists, occurring in a plausible time relationship to drug administration, and which cannot be explained by concurrent disease or other drugs or chemicals.<\/li><li>(A) probable, likely \u2013 sufficient information provided to no other equally plausible explanation exists,<\/li><li>(B) possible \u2013 information provided supports a reasonable time sequence to administrations of the drug, but which could also be explained by another equally possible explanation (i.e. concurrent disease or other drugs or chemicals). Information on drug withdrawal may be lacking or unclear.<\/li><li>(O1) conditional, unclassified \u2013 a clinical event, including laboratory test abnormality, reported as an adverse reaction, about which more data is essential for a proper assessment, or the additional data is under examination.<\/li><li>(O) unassessable, unclassifiable \u2013 a report suggesting an adverse reaction which cannot be judged because information is insufficient or contradictory, and which cannot be supplemented or verified.<\/li><li>(N) unlikely \u2013 a clinical event, including laboratory test abnormality, with a temporal relationship to drug administration which makes a causal relationship improbable, and in which other drugs, chemicals or underlying disease provide plausible explanations<\/li><\/ul>\n\n\n\n<p>It is determined based on:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Temporal relationship, drug\u2019s half-life<\/li><li>Pathological mechanisms<\/li><li>Alternative explanations for the event<\/li><li>Dechallenge and rechallenge<\/li><li>Concomitant diseases or use of other medicines<\/li><li>Previous experience with the drug\u2026<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no other reasonable explanation exists, occurring in a plausible time relationship to drug administration, and which cannot be explained by concurrent disease or other drugs or chemicals. (A) probable, likely \u2013 sufficient information provided to [&hellip;]<\/p>\n","protected":false},"author":232,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[184,180],"tags":[],"type_content":[179],"job":[],"employees_type":[],"class_list":["post-25884","post","type-post","status-publish","format-standard","hentry","category-c","category-glossary","type_content-glossaire","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v19.2.1 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Causal Relationship<\/title>\n<meta name=\"description\" content=\"The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Causal Relationship\" \/>\n<meta property=\"og:description\" content=\"The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/\" \/>\n<meta property=\"og:site_name\" content=\"Ennov Software for Life\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-24T08:52:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dqdev.co\/ennov\/wp-content\/uploads\/2022\/09\/Ennov-Software-for-Life-Hiring.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"627\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Alex Chappell\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@EnnovGroup\" \/>\n<meta name=\"twitter:site\" content=\"@EnnovGroup\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alex Chappell\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/\"},\"author\":{\"name\":\"Alex Chappell\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#\\\/schema\\\/person\\\/ebc4deb7c360f7a979b3af96c6150941\"},\"headline\":\"Causal Relationship\",\"datePublished\":\"2022-10-24T08:52:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/\"},\"wordCount\":232,\"publisher\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#organization\"},\"articleSection\":[\"C\",\"Glossary\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/\",\"url\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/\",\"name\":\"Causal Relationship\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#website\"},\"datePublished\":\"2022-10-24T08:52:13+00:00\",\"description\":\"The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/glossary\\\/causal-relationship\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Causal Relationship\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#website\",\"url\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/\",\"name\":\"Ennov Software for Life\",\"description\":\"Unified Content Management Platform Software for Life Sciences\",\"publisher\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#organization\",\"name\":\"Ennov\",\"url\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/en.ennov.com\\\/wp-content\\\/uploads\\\/2019\\\/02\\\/ennov-social-graph-1.jpg\",\"contentUrl\":\"https:\\\/\\\/en.ennov.com\\\/wp-content\\\/uploads\\\/2019\\\/02\\\/ennov-social-graph-1.jpg\",\"width\":672,\"height\":672,\"caption\":\"Ennov\"},\"image\":{\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/EnnovGroup\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/81570\\\/admin\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/#\\\/schema\\\/person\\\/ebc4deb7c360f7a979b3af96c6150941\",\"name\":\"Alex Chappell\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/ennov-e.png\",\"url\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/ennov-e.png\",\"contentUrl\":\"https:\\\/\\\/dqdev.co\\\/ennov\\\/wp-content\\\/uploads\\\/2022\\\/02\\\/ennov-e.png\",\"caption\":\"Alex Chappell\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Causal Relationship","description":"The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Causal Relationship","og_description":"The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no","og_url":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/","og_site_name":"Ennov Software for Life","article_published_time":"2022-10-24T08:52:13+00:00","og_image":[{"width":1200,"height":627,"url":"https:\/\/dqdev.co\/ennov\/wp-content\/uploads\/2022\/09\/Ennov-Software-for-Life-Hiring.png","type":"image\/png"}],"author":"Alex Chappell","twitter_card":"summary_large_image","twitter_creator":"@EnnovGroup","twitter_site":"@EnnovGroup","twitter_misc":{"Written by":"Alex Chappell","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/#article","isPartOf":{"@id":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/"},"author":{"name":"Alex Chappell","@id":"https:\/\/dqdev.co\/ennov\/#\/schema\/person\/ebc4deb7c360f7a979b3af96c6150941"},"headline":"Causal Relationship","datePublished":"2022-10-24T08:52:13+00:00","mainEntityOfPage":{"@id":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/"},"wordCount":232,"publisher":{"@id":"https:\/\/dqdev.co\/ennov\/#organization"},"articleSection":["C","Glossary"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/","url":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/","name":"Causal Relationship","isPartOf":{"@id":"https:\/\/dqdev.co\/ennov\/#website"},"datePublished":"2022-10-24T08:52:13+00:00","description":"The causal relationship between an\u00a0AE\u00a0and a suspected drug can be, according to the\u00a0WHO: certain\u2013 sufficient information provided to determine that no","breadcrumb":{"@id":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/dqdev.co\/ennov\/glossary\/causal-relationship\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/dqdev.co\/ennov\/"},{"@type":"ListItem","position":2,"name":"Causal Relationship"}]},{"@type":"WebSite","@id":"https:\/\/dqdev.co\/ennov\/#website","url":"https:\/\/dqdev.co\/ennov\/","name":"Ennov Software for Life","description":"Unified Content Management Platform Software for Life Sciences","publisher":{"@id":"https:\/\/dqdev.co\/ennov\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dqdev.co\/ennov\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/dqdev.co\/ennov\/#organization","name":"Ennov","url":"https:\/\/dqdev.co\/ennov\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dqdev.co\/ennov\/#\/schema\/logo\/image\/","url":"https:\/\/en.ennov.com\/wp-content\/uploads\/2019\/02\/ennov-social-graph-1.jpg","contentUrl":"https:\/\/en.ennov.com\/wp-content\/uploads\/2019\/02\/ennov-social-graph-1.jpg","width":672,"height":672,"caption":"Ennov"},"image":{"@id":"https:\/\/dqdev.co\/ennov\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/EnnovGroup","https:\/\/www.linkedin.com\/company\/81570\/admin\/"]},{"@type":"Person","@id":"https:\/\/dqdev.co\/ennov\/#\/schema\/person\/ebc4deb7c360f7a979b3af96c6150941","name":"Alex Chappell","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dqdev.co\/ennov\/wp-content\/uploads\/2022\/02\/ennov-e.png","url":"https:\/\/dqdev.co\/ennov\/wp-content\/uploads\/2022\/02\/ennov-e.png","contentUrl":"https:\/\/dqdev.co\/ennov\/wp-content\/uploads\/2022\/02\/ennov-e.png","caption":"Alex Chappell"}}]}},"_links":{"self":[{"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/posts\/25884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/users\/232"}],"replies":[{"embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/comments?post=25884"}],"version-history":[{"count":1,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/posts\/25884\/revisions"}],"predecessor-version":[{"id":25885,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/posts\/25884\/revisions\/25885"}],"wp:attachment":[{"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/media?parent=25884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/categories?post=25884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/tags?post=25884"},{"taxonomy":"type_content","embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/type_content?post=25884"},{"taxonomy":"job","embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/job?post=25884"},{"taxonomy":"employees_type","embeddable":true,"href":"https:\/\/dqdev.co\/ennov\/wp-json\/wp\/v2\/employees_type?post=25884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}